Effect of tonsillectomy on peripheral blood T cell surface markers and cytokine production in patients with IgA nephropathy accompanied by chronic tonsillitis.
نویسندگان
چکیده
The present study investigated changes in peripheral blood T cell surface markers and cytokines (interleukin-2, IL-2; tumor necrosis factor-alpha, TNF-alpha; and interferon-gamma, IFN-gamma) following tonsillectomy in patients with IgA nephropathy accompanied by chronic tonsillitis. Peripheral blood CD8+ cells, CD45RA+CD4+ cells and CD8+CD11b- cells increased significantly after tonsillectomy, compared with their preoperative values. In some cases, the preoperative serum TNF-alpha and IFN-gamma levels were higher than normal before surgery, but decreased after surgery. These results suggest that tonsillectomy suppresses a decrease in suppressor T cells in patients with IgA nephropathy and corrects abnormal cell-mediated immune responses in these patients.
منابع مشابه
Comparative investigation of the culture of palatine tonsils by superficial and deep methods and investigation of microbial resistance in frequent tonsillitis patients referred for tonsillectomy
Introduction: The tonsils are part of the immune system and tonsillar infection is one of the most common causes of diseases, especially in children. Tonsillitis sometimes does not respond to empirical treatment and the presentation of recurrent tonsillitis eventually leads to tonsillectomy. The aim of this study was to determine and compare palatal tonsil culture by superficial and deep method...
متن کاملThe role of tonsillectomy in pediatric IgA nephropathy.
OBJECTIVES To review pediatric cases of IgA nephropathy (IgAN) in 6 patients who underwent tonsillectomy and had marked improvement of their renal symptoms and to review the appropriate indications for tonsillectomy for this disease. DESIGN Retrospective case series. SETTING Academic medical center. PATIENTS Six children (age range, 8-15 years) with renal biopsy-proved IgAN who were refer...
متن کاملClinical involvement of the tonsillar immune system in IgA nephropathy.
The temporal association of tonsillitis and hematuria or proteinuria in IgA nephropathy suggests that there might be a link between the physiological properties of the secondary lymphoid organ that tonsils represent and the mesangial deposition of IgA characteristic of this nephropathy. A number of clinical and ex-vivo data support this hypothesis. One of the earliest was the demonstration of t...
متن کاملThe immune status in situ of recurrent tonsillitis and idiopathic tonsillar hypertrophy.
OBJECTIVE To analyze the immune status in situ of tonsils of patients with recurrent tonsillitis (RT) and idiopathic tonsillar hypertrophy (ITH) with the aim to discuss the indications of tonsillectomy (TE) and tonsillotomy (TT) in young children. METHODS The histological and immunohistological study of tonsillar tissue of RT and ITH in correlation with immunological parameters in peripheral ...
متن کاملImmunoregulatory cytokines and chronic tonsillitis.
The purposes of the present study were to determine the distribution of cells producing cytokines: tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in different morphological sections of tonsils in patients with tonsillar hypertrophy (TH) and recurrent tonsillitis (RT), to analyze the level of production of these cytokines in TH and RT and evaluate the potential of peripheral blood lymp...
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ورودعنوان ژورنال:
- Nihon Jinzo Gakkai shi
دوره 36 11 شماره
صفحات -
تاریخ انتشار 1994